Science Vol.350 No.6258, 16 October 2015 The Pluto system: Initial results from its exploration by New Horizons 冥王星系统:“新视野”探测的初步成果 S. A. Stern, F. Bagenal, K. Ennico, G. R. Gladstone, W. M. Grundy, W. B. McKinnon, J. M. Moore +ec at. http://www./content/350/6258/aad1815.full
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor 小分子门控的嵌合受体实现远程调控治疗型T细胞 Chia-Yung Wu, Kole T. Roybal, Elias M. Puchner, James Onuffer, and Wendell A. Lim http://www./content/350/6258/aab4077.full
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 活性多梳抑制复合体PCR2催化组蛋白H3K27三甲基化的结构基础 Lianying Jiao and Xin Liu http://www./content/350/6258/aac4383.full
Concise total synthesis of glucosepane glucosepane的简洁全合成 Cristian Draghici, Tina Wang, and David A. Spiegel http://www./content/350/6258/294.full
Hydrogenation of carboxylic acids with a homogeneous cobalt catalyst 一种均相钴催化剂用于羧酸的加氢还原 Ties J. Korstanje, Jarl Ivar van der Vlugt, Cornelis J. Elsevier, and Bas de Bruin http://www./content/350/6258/298.full
CO2 capture from humid flue gases and humid atmosphere using a microporouscoppersilicate 利用微孔铜硅分子筛从潮湿的烟气和大气中捕获CO2 Shuvo Jit Datta, Chutharat Khumnoon, Zhen Hao Lee, Won Kyung Moon, Son Docao, Thanh Huu Nguyen, In Chul Hwang, Dohyun Moon, Peter Oleynikov, Osamu Terasaki, and Kyung Byung Yoon http://www./content/350/6258/302.full
A near–quantum-limited Josephson traveling-wave parametric amplifier 近量子极限的约瑟夫森行波参量放大器 C. Macklin, K. O’Brien, D. Hover, M. E. Schwartz, V. Bolkhovsky, X. Zhang, W. D. Oliver, and I. Siddiqi http://www./content/350/6258/307.full
Sensitivity of seafloor bathymetry to climate-driven fluctuations in mid-ocean ridge magma supply 气候驱动下大洋中脊岩浆供应波动的海底测深敏感性 J.-A. Olive, M. D. Behn, G. Ito, W. R. Buck, J. Escartín, and S. Howell http://www./content/350/6258/310.full
A skin-inspired organic digital mechanoreceptor 皮肤激发的有机数字机械感受器 Benjamin C.-K. Tee, Alex Chortos, Andre Berndt, Amanda Kim Nguyen, Ariane Tom, Allister McGuire, Ziliang Carter Lin +ec at. http://www./content/350/6258/313.full
Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates 对向内在时间梯度引导神经干细胞生成多种神经细胞 Zhiyong Liu, Ching-Po Yang, Ken Sugino, Chi-Cheng Fu, Ling-Yu Liu, Xiaohao Yao, Luke P. Lee, and Tzumin Lee http://www./content/350/6258/317.full
The Atlantic Multidecadal Oscillation without a role for ocean circulation 大西洋多年代际震荡并不受大洋环流影响 Amy Clement, Katinka Bellomo, Lisa N. Murphy, Mark A. Cane, Thorsten Mauritsen, Gaby R?del, and Bjorn Stevens http://www./content/350/6258/320.full
Suboptimization of developmental enhancers 发育增强子的次级优化 Emma K. Farley, Katrina M. Olson, Wei Zhang, Alexander J. Brandt, Daniel S. Rokhsar, and Michael S. Levine http://www./content/350/6258/325.full
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells 濒死细胞的RIPK1和NF-kB信号通路决定CD8阳性T细胞的交叉活化 Nader Yatim, Hélène Jusforgues-Saklani, Susana Orozco, Oliver Schulz, Rosa Barreira da Silva, Caetano Reis e Sousa, Douglas R. Green, Andrew Oberst, and Matthew L. Albert http://www./content/350/6258/328.full 濒死细胞能向树突状细胞(dendritic cell)提供抗原和炎性因子,树突状细胞通过抗原交叉呈递来活化CD8阳性T细胞,从而诱发获得性免疫(adaptive immunity)反应。为了明确不同的细胞程序性死亡形式对免疫反应的影响,我们通过受体相互作用蛋白激酶-3(receptor-interacting protein kinase-3)和半胱天冬酶-8(caspase-8)二聚化分别建立了细胞坏死和细胞凋亡两种模型,发现濒死细胞仅仅释放损伤相关分子模式(damage-associated molecular patterns)等炎性介质是不足以交叉活化CD8阳性T细胞的。相反,强烈的交叉活化需要濒死细胞中受体相互作用蛋白激酶-1(RIPK1)的信号通路和核内因子κB(NF-κB)诱导的转录调控。假设细胞坏死或者炎性凋亡过程中没有NF-κB信号通路,CD8阳性T细胞的交叉活化效率就会大大下降,影响对肿瘤的免疫反应。我们的数据揭示了濒死细胞中炎症和细胞死亡信号通路之间的协调调控着获得性免疫反应。 Stable inhibitory activity of regulatory T cells requires the transcription factor Helios 调节性T细胞的稳定抑制活性需要转录因子Helios Hye-Jung Kim, R. Anthony Barnitz, Taras Kreslavsky, Flavian D. Brown, Howell Moffett, Madeleine E. Lemieux, Yasemin Kaygusuz, Torsten Meissner, Tobias A. W. Holderried, Susan Chan, Philippe Kastner, W. Nicholas Haining, and Harvey Cantor http://www./content/350/6258/334.full 免疫系统的稳态维持需要调节性T细胞(Tregs)。考虑到它们对自身抗原响应的固有特性,Treg细胞必须稳定地维持在抑制性表型来避免自体免疫的发生。本文研究人员报道在小鼠体内,转录因子Helios在FoxP3阳性的CD4 Treg和Qa-1限制型的CD8 Treg中表达减弱,会导致调节功能的缺陷和自身免疫疾病的发生。Helios缺失的Treg细胞在炎症反应中表型不稳定,因STAT5通路活化的减少,这些细胞表现为FoxP3表达量的降低和效应细胞因子表达量的升高。CD8 Treg细胞同样需要Helios依赖的STAT5活化,来提高其生存能力,防止T细胞终末分化。Helios是稳定炎症反应中Treg功能的关键转录因子这一认识,为Treg细胞的核心特征提供了基因层面的解释。 Panoramix enforces piRNA-dependent cotranscriptional silencing Panoramix蛋白驱动piRNA依赖的共转录沉默 Yang Yu, Jiaqi Gu, Ying Jin, Yicheng Luo, Jonathan B. Preall, Jinbiao Ma, Benjamin Czech, and Gregory J. Hannon http://www./content/350/6258/339.full
(来自Sciencemag.com。翻译:张旭阳、史静雯、张雪、徐丽、魏若妍、张奕林;审校:史静雯、杨柳、魏若妍。) |
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