【原】医学影像英语每日读丨70.Multinodular and Vacuolating Neuronal Tumor

每天朗读一段医学影像学英语文章

朗读者：Chester领读

A 30-year-old woman presents with vertigo. MRI demonstrates a cluster of well-delineated, variable-sized FLAIR/T2-hyperintense cysts within the left frontal subcortical white matter, without obvious mass effect or postcontrast enhancement.

Diagnosis: Multinodular and vacuolating neuronal tumor (MVNT)

Multinodular and vacuolating neuronal tumors are a more recently characterized World Health Organization (WHO) grade 1 central nervous system neoplasm. This rare entity has only been described in several case series. 

They are characterized as a benign, mixed glial neuronal lesion consisting of nodules of disorganized neuronal cells located near the subcortical white matter. They are associated with long-term seizures in adults in about 30% of patients, but they are most often found incidentally and are considered "do not touch" or  "leave me alone" lesions if not associated with intractable epilepsy.

30岁女性，患有眩晕。磁共振检查可见左侧额叶皮质下白质边界清晰、形态多样的簇状囊肿，黑水序列呈高信号，未见明显占位效应，增强后未见强化。
诊断：大脑多结节及空泡性神经元肿瘤。
大脑多结节及空泡性神经元肿瘤近期被世界卫生组织归类为1级中枢神经系统肿瘤。该病变仅见几例，十分罕见。
该肿瘤属于良性的胶质神经元混合病灶，病灶内部可见皮质下白质附近的神经元细胞结节排列紊乱。大约30%的成人患者并发长期癫痫发作，病变常偶然发现，若不与颅内难治性癫痫相联系，常被认为是“不要碰”和“别管我”类的病灶。

Notes:

1. Multinodular and Vacuolating Neuronal Tumor (MVNT) 大脑多结节及空泡性神经元肿瘤,是一种良性肿瘤，最近在WHO中枢神经系统肿瘤分类2016年修订版中才被提及，将该肿瘤分在胶质神经元肿瘤-节细胞瘤（亚型）章节内讨论，归属于WHO I级肿瘤。镜下见多结节少突样肿瘤伴空泡变病变，局灶可见小至中等大小的嗜酸胞质的节样神经细胞，免疫组化染色显示，肿瘤细胞抗Hu抗体、Olig-2、syn及CD68阳性，簇状表达CD34。

   Vacuolating ['vækjʊrleɪtɪŋ] adj. 形成空泡的

2. vertigo [ˈvɜ:rtɪgoʊ] n. 眩晕，头晕

3. neoplasm ['ni:oʊplæzəm] n. 肿瘤; 赘生物，（肿）瘤; 新生物

4. glial ['glaɪəl] adj. 神经胶质的

5. seizure ['si:ʒə] 突然发作

6. intractable [ɪnˈtræktəbəl] adj. 难治性的

7. epilepsy ['epɪlepsɪ] 癫痫

来源：每天朗读一段医学影像学英语文章