|
2016年4月27日，美国《肿瘤标靶》杂志在线发表了重庆医科大学附属第一医院分子肿瘤及表观遗传学重庆市重点实验室、新泽西州立罗格斯大学罗伯特·伍德·约翰逊医学院癌症研究所的研究报告：早期乳腺癌患者保乳术后电子组织补偿放疗选择预测参数（通讯作者为任国胜教授）。 Oncotarget. 2016 Apr 27. [Epub ahead of print] Predictive parameters for selection of electronic tissue compensation radiotherapy in early-stage breast cancer patients after breast-conserving surgery. Song Y, Zhang M, Gan L, Chen X, Zhang T, Yue NJ, Goyal S, Haffty B, Ren G. First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, New Brunswick, New Jersey, USA; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic tissue compensation (eComp) is an external beam planning technique allowing user to manually generate dynamic beam fluence to produce more uniform or modulated dose distribution. In this study, we compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and eComp for whole breast irradiation. 3DCRT and eComp planning techniques were used to generate treatment plans for 60 whole breast patients, respectively. The planning goal was to cover 95% of the planning target volume (PTV) with 95% of the prescription dose while minimizing doses to lung, heart, and skin. Comparing to 3DCRT plans, on the average, eComp treatment planning process was about 7 minutes longer, but resulted in lower lung V20Gy, lower mean skin dose, with similar heart dose. The benefits were more pronounced for larger breast patients. Statistical analyses were performed between critical organ doses and patient anatomic features, i.e., central lung distance (CLD), maximal heart distance (MHD), maximal heart length (MHL) and breast separation (BS) to explore any correlations and planning method selection. It was found that to keep the lung V20Gy lower than 20% and mean skin dose lower than 85% of the prescription dose, eComp was the preferred method for patients with more than 2.3 cm CLD or larger than 22.5 cm BS. The study results may be useful in providing a handy criterion in clinical practice allowing us to easily choose between different planning techniques to satisfy the planning goal with minimal increase in complexity and cost. KEYWORDS: 3DCRT; anatomic parameter; breast cancer; electronic tissue compensation; radiotherapy PMID: 27147569 DOI: 10.18632/oncotarget.9054
|
|
|
