三肽-9瓜氨酸Tripeptide-9 citrulline的护肤应用

INCI名称: Tripeptide-9 citrulline

参考名称: dGlyage

Cas No: 951775-32-9

三肽-9瓜氨酸（INCI名称）是一种具有皮肤护理特性的肽，用于化妆品应用。为了阐明其在涉及金属离子的化学途径中的作用机制，利用分光光度法、电化学和电泳技术研究了其络合此类离子的能力。以Cu（II）为金属离子得到的结果与三肽-9瓜氨酸与Cu（II）形成复合物的结果一致。循环伏安法显示了电化学电位的显著变化。体外电泳研究证明三肽-9瓜氨酸可以保护DNA免受芬顿反应诱导的自由基降解。

Tripeptide-9 Citrulline (INCI name) is a peptide with skin care properties, used for cosmetic applications. In order to elucidate its mechanism of action in the chemical pathways that involve metal ions, its ability to complex such ions was investigated using spectrophotometrical, electrochemical and electrophoretical techniques. The obtained results using Cu(II) as metal ion were consistent with the formation of a complex between Tripeptide-9 Citrulline andCu(II). Cyclic voltammetry revealed a significant changein the electrochemical potentials. In-vitro electrophoretic studies served as a proof of concept that Tripeptide-9 Citrullinemay protect DNA from radical degradation induced by the Fenton reaction.

三肽-9瓜氨酸可以防止过渡金属引发的DNA结构变化。它螯合这种离子金属，催化不同的反应产生几种DNA损伤。粒径减小的错流体脂质体含有四肽，因此输送到皮肤。

Tripeptide-9 citrulline prevents DNA structure changes triggered by transition metals.It chelates such ion metals that catalyse different reaction producing several DNA lesions.Miscrofluidised liposomes with diminished particle size contain the tetrapeptide,thus delivery to the skin is enchanced.