lIntracellularsignalingmolecules(second
messengers)areproducedinresponsetothe
activationofGproteinsbycell-surfacereceptors.
ThesecondmessengerscAMPandcGMPare
producedbyadenylatecyclase(腺苷酸环化酶)and
guanylatecyclase(鸟苷酸环化酶),respectively.
lActivationofphospholipaseC(磷酯酶c)leadstothe
productionofthesecondmessengersinositol1,4,5-
trisphosphate(三磷酸肌醇,IP3)and1,2-
diacylglycerol(二脂酰甘油,DAG)whichinturn
2+
causethereleaseofCafromintracellularstores
andactivateproteinkinaseC,respectively. |
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