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日问1038:颅内静脉窦血栓的介入干预指征?

 刘锐Ryan 2022-11-14 发布于陕西

日进一卒,功不唐捐。

今天是咱们一起学习的第 1038 

颅内静脉窦血栓的介入干预指征是?

1. 临床恶化——我们将“临床恶化”定义为尽管进行了最佳的医疗管理,但出现以下任何一种或多种特征的复合终点,且排除了其他原因,如电解质紊乱、尿毒症、肝功能障碍:

(1)与入院时的评分相比,格拉斯哥昏迷评分下降(格拉斯哥昏厥评分<8或运动/言语/睁眼反应下降至少1分)

(2)恶化/新发局灶性神经功能缺损

(3)新发/复发性癫痫

2.颅内高压恶化——我们将“颅内高压恶化”定义为尽管进行了最佳医疗管理,但出现以下任何一种或多种特征的复合终点:

(1)颅内压升高的持续症状(头痛加剧、持续呕吐、心动过缓和高血压)

(2)ICU住院期间的重复成像显示静脉梗死继发的脑水肿/肿块效应恶化

3. 深静脉系统受累(直窦、盖伦静脉和大脑内静脉)

4. 全身抗凝的禁忌症,如严重血小板减少症(血小板<20 000cu mm,活动性全身出血或出血体质)


Definitions for Indications for MT

  1. Clinical deterioration – We defined “clinical deterioration” as a composite end point of occurrence of any 1 or a combination of the following features despite optimal medical management, with other causes like dyselectrolytemia, uremia, hepatic dysfunction being excluded:

    1. Drop in Glasgow Coma Score when compared with the score at admission (Glasgow Coma Score<8 or drop by at least 1 point in either motor/verbal/eye opening responses)

    2. Worsening/new onset focal neurological deficits

    3. New onset/recurrent seizures

  2. Worsening intracranial hypertension – We defined “Worsening intracranial hypertension” as a composite endpoint of occurrence of any 1 or a combination of the following features despite optimal medical management:

    1. Persistent symptoms of raised intracranial pressures (increased headache, protracted vomiting, bradycardia, and hypertension)

    2. Repeat imaging during the course of ICU stay showing worsening cerebral edema/mass effect secondary to venous infarction

  3. Involvement of deep venous system (straight sinus, vein of Galen, and internal cerebral veins)

  4. Contraindication to systemic anticoagulation such as severe thrombocytopenia (platelets <20 000cu mm, active systemic bleeding or bleeding diathesis)


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整理编辑:
刘锐 | 医生
南京大学神经病学研究所
金陵医院(医院还有个名字,有纪律网上不让说全称,自行查地址)
南京市玄武区中山东路305号



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