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①Brenner tumour Brenner瘤 Definition Brenner tumour is a tumour composed of nests of bland transitional/urothelial epithelium set within a dense fibromatousstroma. 定义 Brenner瘤是一种由温和的移行上皮/尿路上皮细胞巢组成的肿瘤，位于致密的纤维瘤性间质中。 ICD-O coding 9000/0 Brenner tumour NOS ICD-O编码 9000/0 Brenner瘤NOS Essential and desirable diagnostic criteria Essential: tumours with nests of bland transitional/urothelial epithelium set within fibromatous stroma. 必需和理想的诊断标准 必需:形态温和的移行/尿路上皮细胞巢位于纤维瘤性间质中。  Fig.1.58 Brenner tumour. Small nests and cysts in a fibromatous background. 图1.58 Brenner瘤。小巢状和囊性结构位于纤维瘤性背景中。
Fig. 1.59 Brenner tumour. A Transitional/urothelial nests (some of which show cyst formation) are in a fibromatous stroma. B Characteristic cytological features include uniform oval cells with pale cytoplasm, nuclei with occasional grooves, fine chromatin, and small nucleoli. 图1.59 Brenner瘤。A移行/尿路上皮巢(其中部分有囊腔形成)位于纤维瘤性间质中。B细胞学特征包括一致的卵圆形细胞，胞质淡染，偶有核沟，染色质细，核仁小。 ②Borderline Brenner tumour 交界性Brenner瘤 Definition Borderline Brenner tumour is a tumour of transitional/urothelial epithelium displaying papillary architecture and lacking stromal invasion. 定义 交界性Brenner瘤是一种移行/尿路上皮肿瘤，呈现乳头状结构，缺乏间质浸润。 ICD-O coding 9000/1 Brenner tumour, borderline malignancy ICD-O编码 9000/1Brenner瘤，交界性恶性肿瘤 Essential and desirable diagnostic criteria Essential: papillary growth resembling low-grade papillary urothelial neoplasms of the urothelial tract or (rarely) crowded nests of transitional/urothelial epithelium, without stromal invasion. Desirable: a benign Brenner component. 必需和理想的诊断标准 基本特征:乳头状生长，类似于尿路低级别乳头状尿路上皮肿瘤，或(罕见)拥挤的移行/尿路上皮巢，无间质浸润。 理想的:良性Brenner瘤成分。
Fig. 1.60 Borderline Brenner tumour. A This tumour shows a prominent papillary growth pattern. B The papillae are lined by transitional-type epithelium with scattered pleomorphic cells. 图1.60交界性Brenner瘤。A肿瘤呈明显的乳头状生长。B乳头衬覆移行上皮，其中有散在的多形性细胞。
Fig. 1.61 Borderline Brenner tumour. A This tumour shows an endophytic, ribbon-like growth pattern. B Cytologically, this tumour shows uniform transitional-type epithelium. 图1.61交界性Brenner瘤。A肿瘤显示内生性、带状生长模式。B细胞学上，该肿瘤显示一致的移行上皮。 ③Malignant Brenner tumour 恶性Brenner瘤 Definition Malignant Brenner tumour is anovariancarcinoma resembling an invasive urothelial carcinoma, associated with benign or borderline Brenner tumour. 定义 恶性Brenner瘤是一种类似于浸润性尿路上皮癌的卵巢癌，与良性或交界性Brenner瘤相关。 ICD-O coding 9000/3 Brenner tumour, malignant ICD-O编码 9000/3 Brenner瘤，恶性 Essential and desirable diagnostic criteria Essential: Malignant tumour with urothelial differentiation; a benign or borderline Brenner tumour component in the background. 必需和理想的诊断标准 必需：恶性肿瘤伴尿路上皮分化;背景中有良性或交界性Brenner瘤成分。
Fig. 1.62 Malignant Brenner tumour. A Solid confluent and papillary tumour growth with residues of a benign Brenner tumour at the lower edge. B Confluent sheets of tumour with solid growth and pseudoglandular structures. C GATA3 is positive in the esidual benign component but lost in the malignant Brenner tumour. 图1.62恶性Brenner瘤。A肿瘤呈实性融合和乳头状生长，下方有良性Brenner瘤残余。B肿瘤融合成片，实性生长和假腺样结构。C GATA3在残余的良性肿瘤中呈阳性，但在恶性Brenner瘤中呈阴性。 整理：南瓜子儿 审核：樊月 设计：鹏飞 编辑：雅芸 |
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