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活性氧1,5-Dicaffeoylquinic Acid,19870-46-3

 齐岳hao 2023-04-26 发布于陕西

产品名称:活性氧1,5-Dicaffeoylquinic Acid,19870-46-3

产地:西安

规格:1mg 5mg 10mg

纯度:99%

用途:仅用于科研

状态:固体/粉末

储藏条件:冷藏-20℃

温馨提示:仅用于科研,不能用于人体实验!

说明:提供使用说明,核磁图谱,包装,价格,产地,制备方法,应用,稳定性,溶解度,简单合成等各种信息  

1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger.1,2 1,5-DCQA inhibits HIV-1 integrase 3' end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively.2 It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in a dose-dependent manner.1 It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 µM.

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编辑:XAQYBIO HAO,2023年4月23日。

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