156
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Conclusion
Vconhumnaplacentahemoglobin-basedoxygencarriers.The14th
InternationalSymposiumofBloodSubstitutesandOxygenThera-
Inthiswork,themolybdenumbluemethodwasusedtodetect
peutics.Chengdu,China.
theVccontentinthesolutionofHBOCs,andtheconditions
DormanSC,KennyCF,MillerL,HirschRE,HarringtonJP.2002.Roleof
ofthecolorimetricreactionwereoptimized.Theresultsshow
redoxpotentialofhemoglobin-basedoxygencarriersonmethemo-
globinreductionbyplasmacomponents.ArtifCellsBloodSubstit
thatHBOCscouldbeisolatedeffectivelybytheOA-EDTAsolu-
ImmubilBiotechnol30:39–51.
tionwithHClastheacidicmedium,whichhasnointerferen-
EldawyMA,TawfikAS,ElshabouriSR.1975.Rapid,sensitivespectro-
tialeffectsonthereaction.TheRSDofthedatafrommethod
photometricmethodforthedeterminationofascorbicacid.Anal
Chem47:461–464.
validationwerebelow5%,andtherecoverieswerebetween
HarringtonJP,OrligK,ZitoSL,WollockoJ,WollockoH.2010.Struc-
97%and102%.Inconclusion,themolybdenumbluemethod
turalandredoxbehaviorofOxyVitaTM,azero-linkedpoly-
candetecttheVccontenteffectivelyinthesolutionofHBOCs,
merichemoglobin:comparisonwithnaturalacellularpolymeric
hemoglobins.ArtifCellsBloodSubstitImmubilBiotechnol38:
andthushaspotentialapplicationindevelopmentofHBOCs
64–68.
duetoitsconvenient,low-cost,andsimpleoperation.
LiT,ZhangH,WangH,YuR,YangC.2006.Purificationandviralinac-
tivationofhemoglobinfromhumanplacentablood.JBiomedEng
23:640–644.
Declarationofinterest
LinbergR,ConoverCD,ShumKL,ShorrRG.1998.Hemoglobin-based
oxygencarriers:howmuchmethemoglobinistoomuch?ArtifCells
Theauthorsreportnodeclarationsofinterest.Theauthors
BloodSubstitImmubilBiotechnol26:133–148.
MatsuokaY,YamatoM,YamasakiT,MitoF,YamadaK.2012.Rapidand
aloneareresponsibleforthecontentandwritingofthe
convenientdetectionofascorbicacidusingafluorescentnitroxide
paper.
switch.FreeRadicBiolMed53:2112–2118.
Theauthorsaregratefultothefinancialsupportfrom
PaixaoTR,LowinsohnD,BertottiM.2006.Useofanelectrochemi-
callyetchedplatinummicroelectrodeforascorbicacidmappingin
theNationalHighTechnologyResearchandDevelop-
oranges.JAgricFoodChem.54:3072–3077.
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SakaiH,NgK,LiB,SugimuraN.2013.Swinehemoglobinasapoten-
theScienceandTechnologysupportprogramofSichuan
tialsourceofartificaloxygencarriers,hemoglobin-vesicles.Artif
CellsNanomedBiotechnol41:37–41.
ProvinceinChina(No.2013SZ0059),andtheInnovation
SayedElnenaeyE,SolimanR.1979.Asensitivecolorimetricmethodfor
projectofSichuanProvinceinChina(No.2013ZZ0006).
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