RevIew
C-terminalphosphorylationsite.J.Biol.chem.278,41585–41588(2003).activation.nat.immunol.5,503–507(2004).
121.Hua,Z.C.,Sohn,S.J.,Kang,C.,Cado,D.&winoto,A.AfunctionofFas-associated132.Cusson-Hermance,N.,Khurana,S.,Lee,T.H.,Fitzgerald,K.A.&Kelliher,M.A.Rip1
deathdomainproteinincellcycleprogressionlocalizedtoasingleaminoacidatitsmediatestheTrif-dependenttoll-likereceptor3-and4-inducedNF-κBactivationbut
C-terminalregion.immunity18,513–521(2003).doesnotcontributetointerferonregulatoryfactor3activation.J.Biol.chem.280,
122.Arechiga,A.F.etal.AFas-associateddeathdomainprotein/caspase-8-signalingaxis36560–36566(2005).
promotesS-phaseentryandmaintainsS6kinaseactivityinTcellsrespondingto133.Yamamoto,M.etal.RoleofadaptorTRIFintheMyD88-independenttoll-likereceptor
IL-2.J.immunol.179,5291–5300(2007).signalingpathway.science301,640–643(2003).
123.Misra,R.S.etal.Caspase-8andc-FLIPLassociateinlipidraftswithNF-κBadaptors134.Sato,S.etal.Toll/IL-1receptordomain-containingadaptorinducingIFN-β(TRIF)
duringTcellactivation.J.Biol.chem.282,19365–19374(2007).associateswithTNFreceptor-associatedfactor6andTANK-bindingkinase1,and
124.Ch’en,I.L.etal.Antigen-mediatedTcellexpansionregulatedbyparallelpathwaysactivatestwodistincttranscriptionfactors,NF-κBandIFN-regulatoryfactor-3,in
ofdeath.Proc.natl.acad.sci.usa105,17463–17468(2008).theToll-likereceptorsignaling.J.immunol.171,4304–4310(2003).
Geneticablationofcaspase-8,NF-κBandRIP1revealstwoformsofcelldeaththat135.Yoshida,R.etal.TNFreceptor-associatedfactor(TRAF)6andMeKkinase(MeKK)1
canregulateT-cellproliferation.playapivotalroleintheretinoic-acid-induciblegene-I(RIG-I)-likehelicaseantiviral
125.Monks,C.R.,Kupfer,H.,Tamir,I.,Barlow,A.&Kupfer,A.Selectivemodulationofpathway.J.Biol.chem.283,36211–36220(2008).
proteinkinaseC-θduringT-cellactivation.nature385,83–86(1997).136.Maelfait,J.etal.StimulationofToll-likereceptor3and4inducesinterleukin-1β
126.Sun,S.C.&Ley,S.C.NewinsightsintoNF-κBregulationandfunction.trendsmaturationbycaspase-8.J.exp.med.205,1967–1973(2008).
immunol.29,469–478(2008).Suggestsanewroleforcaspase-8intheproductionofbiologicallyactiveIL-1βin
127.wu,C.J.&Ashwell,J.D.NeMOrecognitionofubiquitinatedBcl10isrequiredforresponsetoTLR3andTLR4stimulation.
Tcellreceptor-mediatedNF-κBactivation.Proc.natl.acad.sci.usa105,3023–137.Kaiser,w.J.&Offermann,M.K.Apoptosisinducedbythetoll-likereceptoradaptor
3028(2008).TRIFisdependentonitsreceptorinteractingproteinhomotypicinteractionmotif.
128.Shambharkar,P.B.etal.PhosphorylationandubiquitinationoftheIκBkinasecom-J.immunol.174,4942–4952(2005).
plexbytwodistinctsignalingpathways.emBoJ.26,1794–1805(2007).138.Sun,H.etal.TIPe2,anegativeregulatorofinnateandadaptiveimmunitythat
129.Kawadler,H.,Gantz,M.A.,Riley,J.L.&Yang,X.TheparacaspaseMALT1con-maintainsimmunehomeostasis.cell133,415–426(2008).
trolscaspase-8activationduringlymphocyteproliferation.mol.cell31,415–421IdentifiesTIPE2asanimportantnegativeregulatorofcaspase-8–mediatedproin-
flammatoryactivity.
(2008).
139.Pietras,e.M.&Cheng,G.AnewTRADDitioninintracellularantiviralsignaling.sci.
TheparacaspasedomainofMALT1(oftheCBMcomplex)inducescaspase-8acti-
vationthroughadirectinteraction.Implicationofc-FLIP/caspase-8associationinsignal.1,pe36(2008).
TCR-mediatedNF-κBactivation.140.Oganesyan,G.etal.CriticalroleofTRAF3intheToll-likereceptor-dependentand
130.Liu,Y.C.Thee3ubiquitinligaseItchinTcellactivation,differentiation,andtoler--independentantiviralresponse.nature439,208–211(2006).
ance.semin.immunol.19,197–205(2007).141.Saha,S.K.etal.Regulationofantiviralresponsesbyadirectandspecificinteraction
131.Meylan,e.etal.RIP1isanessentialmediatorofToll-likereceptor3-inducedNF-κBbetweenTRAF3andCardif.emBoJ.25,3257–3263(2006).
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