Inhibitors?Screening Libraries?ProteinsMedChemExpressTeicoplanin sodiu
mCat. No.:HY-A0097ACAS No.:184539-13-7Synonyms:Antibiotic MDL-507
sodium; MDL-507 sodium作用靶点:Antibiotic; HIV; SARS-CoV作用通路:Anti-in
fection储存方式:Please store the product under the recommended condit
ions inthe Certificate of Analysis.BIOLOGICAL ACTIVITY生物活性Teicopl
anin sodium (Antibiotic MDL-507 sodium) 是一种有效的脂糖肽类抗生素。Teicoplanin
sodium 对HIV-1、SARS-CoV1 和 SARS-CoV2 显示出抗病毒活性。Teicoplanin sodium
具有抗 MRSA 活性。IC50 & TargetMRSA [2]体外研究Teicoplanin sodium shows ant
iviral activity with IC50s of 0.39, 1.66, 15.7 μM for HIV-luc/SAR
S-CoV-Spseudotyped viruses in HEK293T cells, 2019-nCoV-Spike-pseu
doviruses in A549 cells, SARS-CoV-2 in VeroE6 cells, respectively
[1].Teicoplanin sodium can inhibit HIV-1 virus in human CEM cell
culture with EC50 value of 17 μM [1].The mechanism is the inhibi
tion of the cathepsin L protease through the interaction of the t
eicoplaninlipophilic moiety with the enzyme and inhibits cathepsi
n L activity, stops the SARS-CoV release from the lateendosome [1
].Teicoplanin sodium shows anti-MRSA activity with MICs of 0.5 mg
/L in MRSA ATCC 43300 [2].体内研究Teicoplanin sodium (10, 30 mg/kg; i
.v.) shows a dose-dependent decline in the total bacterial densit
y inmurine MRSA thigh infection model [2].Animal Model:20-30 g, M
ale CD1 mice (2 106 cfu/mL MRSA (43?300) 50 μL; murine thigh in
fectionmodel) [2]Dosage:10, 30 mg/kgAdministration:I.v.; once eve
ry 12?h1/2Master of Bioactive Molecules — 您身边的抑制剂大师MedChemExpress
Result:Showed a dose-dependent decline in the total bacterial den
sity with the total bactericidal effect was achieved with dosages
of ≥10?mg/kg/day and suppression of resistance with dosages ≥30?
mg/kg/day.客户使用本产品发表的科研文献?Infect Drug Resist. 2021 Dec 16;14:5449-
5456.See more customer validations on www.MedChemExpress.cnREFERE
NCESVimberg V. Teicoplanin-A New Use for an Old Drug in the COVID
-19 Era? Pharmaceuticals (Basel). 2021 Nov 26;14(12):1227.Ramos-M
artín V, et al. Pharmacodynamics of teicoplanin against MRSA. J A
ntimicrob Chemother. 2017 Dec 1;72(12):3382-3389.McePdfHeightCaut
ion: Product has not been fully validated for medical applications.For research use only.2/2Master of Bioactive Molecules — 您身边的抑制剂大师 |
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